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KMID : 0861020120270020047
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Korea Journal of Herbology
2012 Volume.27 No. 2 p.47 ~ p.51
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Effects of Ginseng Radix on sperm count and CatSper3, 4 proteins expression in Male Mice
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Park Eun-Hwa
Kim Do-Rim
Park Seong-Kyu
Chang Mun-Seog
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Abstract
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Objectives: The purpose of this study was to investigate the reproductive effect of Ginseng radix on male mice.
Methods: Male C57BL/6J mice were divided into four groups； normal group (vehicle-treated, n=8), Ginseng
radix treatment group (100, 500, 1000 mg/kg, n=8). Ginseng radix extract was treated for 5 weeks. After
treatment each group was examined for assessment of sperm count and CatSper protein expression using
computer assisted semen analysis (CASA) system and the immunofluorescence.
Results: Sperm count of normal and Ginseng radix extract treated group were 287.57 vs. 371.62, 364.83,
343.29 x106, respectively. The CatSper3, 4 proteins expression of Ginseng radix treated group were significantly
increased than that of normal group.
Conclusions: These findings suggest that the Ginseng radix improves male reproductive function by increasing
sperm count and CatSper protein expression.
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KEYWORD
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Ginseng radix, Sperm count, Cation channel of Sperm (CatSper)
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